Spring 2006



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Controlling Diabetes Before Pregnancy

By Danielle M. Esters, MD, FACOG

Photo of woman checking her blood glucose level
Diabetes is a medical condition in which there are abnormally high levels of blood glucose due to defects in insulin production, insulin action or both. Of the 8.1 million women with diabetes in the United States, almost 25 percent are of childbearing age.

Poorly controlled diabetes prior to conception and during the fi rst trimester of pregnancy may cause major birth defects in 5 to 10 percent of pregnancies, and miscarriages in 15 to 20 percent of pregnancies. This startling statistic demonstrates how important it is that would-be moms control diabetes before becoming pregnant.

During early pregnancy, before a woman may even know she is pregnant, cells contribute to organ formation in the developing embryo. High blood glucose levels may interrupt proper organ formation and cause malformations in the fetal brain, spinal cord, heart, kidneys and limbs. Controlling blood glucose levels once pregnancy is diagnosed may be too late to prevent miscarriage or congenital defects. The good news is that the chance of these problems occurring in pregnancy may be decreased by adequately controlling blood glucose levels before conceiving.

The preconception consultation is a vital aspect of care for women with diabetes who are considering pregnancy. Preconception is the time to more strictly monitor glucose levels and possibly adjust diabetes therapy. Nonpregnant women with diabetes treated with oral medication will likely need to switch to insulin. Women already being treated with insulin may need dosage adjustments to achieve glucose control that is acceptable for pregnancy. The preconception period is also a good time to make needed dietary modifi cations. If weight loss is needed, this should be attempted before becoming pregnant, not during pregnancy.

Once pregnant, frequent glucose monitoring during the day is needed to confi rm optimal glucose control and is essential for the entire pregnancy through delivery. Although pregestational diabetes is a signifi cant risk factor, adverse effects to the pregnancy may be reduced by appropriate preconceptional and antenatal care.

Photo of Danielle M. Esters, MD, FACOG
Danielle M. Esters, MD, FACOG, is a maternalfetal medicine specialist and is board certifi ed in obstetrics and gynecology, maternal-fetal medicine and clinical medical genetics. She is in private practice in West Palm Beach and receives patients with diabetes and other complications of pregnancy for prenatal care as well as for consultation from referring doctors. For an appointment, please call 561-790-0472.

Wellington Regional Medical Center,
10101 Forest Hill Blvd.
Wellington, FL 33414
(561) 798-8500