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By Danielle M. Esters, MD, FACOG
Poorly controlled diabetes prior to
conception and during the fi rst trimester
of pregnancy may cause major birth
defects in 5 to 10 percent of pregnancies,
and miscarriages in 15 to 20 percent
of pregnancies. This startling statistic
demonstrates how important it is that
would-be moms control diabetes before
becoming pregnant.
During early pregnancy, before a
woman may even know she is pregnant,
cells contribute to organ formation in
the developing embryo. High blood
glucose levels may interrupt proper organ
formation and cause malformations in the
fetal brain, spinal cord, heart, kidneys and
limbs. Controlling blood glucose levels
once pregnancy is diagnosed may be too
late to prevent miscarriage or congenital
defects. The good news is that the chance
of these problems occurring in pregnancy
may be decreased by adequately
controlling blood glucose levels before
conceiving.
The preconception consultation is
a vital aspect of care for women with
diabetes who are considering pregnancy.
Preconception is the time to more strictly
monitor glucose levels and possibly
adjust diabetes therapy. Nonpregnant
women with diabetes treated with
oral medication will likely need to
switch to insulin. Women already being
treated with insulin may need dosage
adjustments to achieve glucose control
that is acceptable for pregnancy. The
preconception period is also a good time
to make needed dietary modifi cations.
If weight loss is needed, this should be
attempted before becoming pregnant, not
during pregnancy.
Once pregnant, frequent glucose
monitoring during the day is needed to
confi rm optimal glucose control and is
essential for the entire pregnancy through
delivery. Although pregestational diabetes
is a signifi cant risk factor, adverse
effects to the pregnancy may be reduced
by appropriate preconceptional and
antenatal care.
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